Paracetamol

Paracetamol is a common medicine to everybody. It is most useful and well known to everybody. All of doctors prescribe this medicine often. There is no man who does not use paracetamol. Somebody uses this medicine without suggestion of doctor. But it is very risky to use any kind of medicine without prescription of a doctor.


PARACETAMOL

Paracetamol is a common medicine to everybody. It is most useful and well known to everybody. All of doctors prescribe this medicine often. There is no man who does not use paracetamol. Somebody uses this medicine without suggestion of doctor. But it is very risky to use any kind of medicine without prescription of a doctor.

PHARMACOLGY

Paracetamol is the formulation of Paracetamol, which is one of the safest and most widely used analgesic and antipyretic. Paracetamol produce analgesic action by elevation of the pain threshold and antipyretic through action on the hypothalamic heat regulation centre. Paracetamol exerts significantly milder side effects and most unlikely to produce many of the serious side effects associated with aspirin and other NSAIDs. Paracetamol is rapidly and completely absorbed from the G.I.T. following oral administration and from rectum after rectal administration. The mean half-life of absorption from the upper small intestine is only 7 minutes. The drug is extensively metabolized in the liver and it has a plasma half- life 1.5 to 3.0 hours. Paracetamol is not bound to plasma proteins to any extent.

INDICATION

Fever, Common cold and influenza, Headache, Toothache, Earache, Body ache, Myalgia, Dysmenorrheal, Neuralgia and Sprains. Pain of colic, back pain, post-operative pain, chronic pain of cancer, inflammatory pain and post vaccination pain and fever of children. Rheumatism and osteoarthritis pain & stiffness of joints in fingers, hips, knees, wrist, elbows, feet, ankles and top & bottom of the spine.

DOSAGE AND ADMINISTRATION

Adult : 1-2 tablets every 4 to 6 hours up to a maximum of (8 tablets) daily.
Children : (6-12) years ½ to 1 tablets 3 to 4 times daily. For long term
treatment, It is wise not to exceed the dose beyond 2.6gm/day.


SYRUP and SUSPENSION

Children Under 3 months : 10mg/kg body weight (reduce to 5 mg/kg if jaundiced)
3 to 4 times daily
3 months to below 1 year: ½ teaspoonful 3 to 4 times daily.
6-12 years : 2-4 teaspoonfuls 3 to 4 times daily.
Adults :4-8 teaspoonfuls 3 to 4 times daily.

CONTRAINDICATION

Known sensitivity to paracetamol.

SIDE EFFECTS

Side effects are significantly mild, though hematological reactions have been reported. Pancreatitis, Skin rashes and other allergic reactions occur occasionally


OVER DOSE

Moderate overdose : 4-10gm/day
Excessive overdose : More than 10mg/day.

Symptoms of overdose include pallor, nausea, vomiting, anorexia & abdominal pain. Liver damage may become apparent 12-48 hours after ingestion.

In severe poisoning hepatic failure may progress to encephalopathy, coma & DEATH.


example- Ace, Napa, Reset, Renova, Xcel

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